RosettaMHCII models of cancer epitope/MHC-II complexes

Select Cancer Epitope:

Epitope and Rosetta modeling info:

NetMHCIIpan-4.1 predictions:

Download model

(To navigate: Use your mouse or track pad to orient the pMHC-II complex with the straight α1-helix toward the top of the screen on the back side of the molecule. Orient the bent β1-helix toward the top of the screen on the front side of the molecule. The peptide sequence can then be read left to right, i.e. N- to C-terminus). Hold control to move the molecule up and down.

Left: Per residue energy in the RosettaMHCII model. Right: Per residue solvent-accessible surface area (SASA) in the RosettaMHCII model.